RA complications affecting the nervous system both the central and peripheral nervous systems can occur from inflammation of the small blood vessels vasculitis that feed the nerves, with immune system cells and chemicals causing nerve damage demyelinationor from compression of the nerves by damaged joints and related structures.
Examples of the latter include carpal tunnel syndrome, with nerve symptoms affecting the hand and fingers, and cervical spine involvement resulting in compression of the spinal cord, causing pain and sensory loss in the hands and feet.
Additionally, nerve symptoms can result as side effects from the many medications that are used to treat RA, including glucocorticoids, non-steroidal anti-inflammatory drugs NSAIDsand disease-modifying anti-rheumatic drugs DMARDsincluding newer biologic treatments.
Non-compressive nerve symptoms result from inflammation that affects the nerve directly, resulting in demyelination, a process where the outer protective layer of the nerve myelin is damaged, and damage to the axon the part of the nerve cell that transmits electrical nerve impulses. The most common arthritis ulnar nerve of this non-compressive nerve damage include loss of the ability to extend the wrist wrist drop or move the toes or ankle upward foot dropas in the motion used for walking.
Nerve compression also called entrapment can occur early in the course of RA, as changes take place in joints, resulting in direct pressure on nerves located in proximity to joint structures.
The most common example of this is carpal tunnel syndrome, a condition that affects as many as two-thirds of RA patients. In carpal tunnel syndrome, inflammation affects the tendons and ligaments that surround the median nerve, which runs through the carpal tunnel in the wrist into the thumb side of the hand, arthritis ulnar nerve.
Inflamed tendons and ligaments compare razadyne and aricept the nerve producing stinging pain, numbness, and tingling, affecting the first three fingers and the thumb side of the hand. Pain and abnormal sensations are made worse by repetitive movements and nerve symptoms may even involve the forearm and upper arm. Nerve entrapment disorders similar to carpal tunnel syndrome may also occur with the ulnar nerve in the elbow called cubital tunnel syndrome and the tibial nerve that runs along the inner leg near the ankle called tarsal tunnel syndrome.
Tarsal tunnel syndrome can result in numbness and other abnormal sensations burning, arthritis ulnar nerve, tingling, and electrical sensations in the foot, affecting the big toe, first three toes, and the heel. RA-related inflammation may affect the cervical spine, causing swelling in the joints between vertebra specifically the atlas and the axisarthritis ulnar nerve, which can cause compression of the spinal cord. Compression of the spinal cord may result in a range of symptoms, including neck pain on movementheadache, weakness, arthritis ulnar nerve, abnormal reflexes, loss of normal sensation in various parts of the body, and changes in blood pressure and breathing.
While these effects may only occur in a minority of patients, they may explain certain nerve symptoms experienced by patients with RA.
For example, corticosteroid treatment can be associated with cognitive dysfunction, hypomania, and depression and arthritis ulnar nerve DMARD methotrexate can be associated arthritis ulnar nerve headache and impairment of the ability to concentrate.
Treatment of RA-related nerve symptoms depends on the nature, location, and severity of the symptom. In cases where inflammation of joints in the cervical spine is causing nerve compressioninterventions that may be useful in controlling pain include use of a neck brace or collar and application of heat or cold.
Spinal manipulation should not be used in patients with RA-related involvement in the cervical spine, arthritis ulnar nerve. Additionally, surgical intervention including fusion of vertebra may used to address nerve symptoms. Let us know at contact RheumatoidArthritis, arthritis ulnar nerve. Try again or let us know at contact RheumatoidArthritis. Twitter Created with Sketch. Email Created with Sketch. Possible nervous system side effects with RA medications, arthritis ulnar nerve.
Extra-articular manifestations of rheumatoid arthritis: Rheumatoid arthritis treatments beyond the arthritis ulnar nerve. Rheumatoid arthritis of the cervical arthritis ulnar nerve considerations. Cervical subluxation in rheumatoid arthritis. Carpal tunnel syndrome fact sheet. The Storms in my Joints by Wren.